Indian Journal of Cerebral Palsy

REVIEW ARTICLE
Year
: 2016  |  Volume : 2  |  Issue : 2  |  Page : 71--78

Neuronal apoptosis of the developing brain: Influence of anesthetics


Padmaja Durga 
 Department of Anesthesiology and Intensive Care, Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India

Correspondence Address:
Padmaja Durga
Department of Anesthesiology and Intensive Care, Nizam's Institute of Medical Sciences, Hyderabad, Telangana
India

Surgeries and multiple procedures are undertaken on millions of children all over the world which involves exposure of these children to anesthetics during the stage of brain development. There is an increasing concern regarding the risk of anaesthetic neurotoxicity in children. Evidence has shown that exposure to all commonly used anaesthetics and sedatives can cause neurodegeneration in the developing brain with the possible exception of α2-adrenergic agonists. Anaesthetic effects on the brain during its growth spurt can initiate a cascade of alterations in neurodevelopment which have been detected structurally or functionally in preclinical experiments. The studies are ongoing to gather clinical evidence.


How to cite this article:
Durga P. Neuronal apoptosis of the developing brain: Influence of anesthetics.Indian J Cereb Palsy 2016;2:71-78


How to cite this URL:
Durga P. Neuronal apoptosis of the developing brain: Influence of anesthetics. Indian J Cereb Palsy [serial online] 2016 [cited 2019 Mar 22 ];2:71-78
Available from: http://www.ijcpjournal.org/article.asp?issn=2395-4264;year=2016;volume=2;issue=2;spage=71;epage=78;aulast=Durga;type=0